A new refrigerator-sized factory can rapidly pump out a diverse assortment of drugs on demand.

Researchers designed the system to offer a speedy alternative to large-scale pharmaceutical production. Rejiggering chemical inputs and the device’s collection of tanks and tubes allowed the team to produce four different drugs: an anesthetic (lidocaine), an antihistamine (Benadryl), an anti-anxiety medication (Valium) and an antidepressant (Prozac). The self-contained system was equipped to mix, heat, pump and purify ingredients into hundreds to thousands of doses of pharmaceutical-grade compounds. Making each medication took the device between roughly 12 and 50 hours, the team reports in the April 1 Science. Attached computers allow one person to control and monitor the whole process.

For now, the device only makes liquid medications. But it may be a step toward overcoming limitations of cumbersome drug-making supply chains by developing automated tools that make medications on demand.

The Kepler space telescope, NASA’s premier planet hunter, is about to embark on a hunt for planets toward the center of the galaxy. But on April 7, just hours before its new mission was set to begin, the observatory gave astronomers a scare by temporarily hunkering down in an emergency state that prevented mission controllers from communicating with the spacecraft. As of April 11, though, Kepler was talking to Earth again, and engineers are getting the telescope prepped for its new quest.

“A cause has not been determined; that will take time,” says NASA spokesperson Michelle Johnson. “The priority is returning the spacecraft to science mode.”
Kepler has previously had problems with its reaction wheels, which are necessary for keeping the spacecraft pointed in the right direction. After two of its wheels stopped working, the telescope took a break from planet hunting in 2013. Engineers at Ball Aerospace figured out how to get Kepler working again with the two remaining wheels by using pressure from sunlight to balance the telescope. While engineers don’t yet know why Kepler shut down this time, early reports indicate that the remaining reaction wheels are not to blame.

Once the spacecraft checks out, Kepler will kick off its latest effort, looking toward the galactic center for planets whose gravity distorts the light from far more distant stars. This technique, known as gravitational microlensing, has been used with ground-based telescopes to discover about 46 planets, some of them orphaned from their parent stars. But the method is a first for Kepler, which searches for dips in starlight caused by planets crossing in front of their suns.

This phase of Kepler’s mission will last until July 1. Even if it doesn’t turn up any new exoplanets, it’s guaranteed to see at least one world: To look at the center of the galaxy, Kepler has to point toward Earth. The telescope that has spent over half a decade searching for other worlds will snap a picture of our planet that will be released later this year.

SALT LAKE CITY — When black holes collide, astronomers expect to record a gravitational wave “chirp.” But rapidly spinning black holes, like the one featured in the 2014 film Interstellar, might prefer singing to chirping.

According to the calculations of Caltech physicist Kip Thorne, who served as scientific consultant for Interstellar, the movie’s black hole, known as Gargantua, must have had a mass 100 million times that of the sun and whirled about its own axis at breakneck speeds. These characteristics would explain the extreme time dilation on the world where the film’s intrepid planet hunters landed: In one hour there, seven elapsed on Earth, a phenomenon predicted by Einstein’s general theory of relativity.
If a rapidly spinning black hole merges with a companion, it would produce a unique signal — one that gravitational wave detectors might be able to observe, physicist Niels Warburton of MIT reported April 18 at a meeting of the American Physical Society. “There is a completely different gravitational wave signature,” said Warburton, who coauthored a related paper posted online at arXiv.org on March 3.

The standard signal of merging black holes is a “chirp,” named for the increase in frequency and amplitude of the gravitational waves produced as the black holes spiral inward. When converted into sound waves, this pattern sounds like a bird’s chirp. Warburton and colleagues performed calculations to determine the gravitational wave signature from a merger with a black hole spinning at nearly full tilt. Instead of a chirp, they found the gravitational waves would instead maintain a constant pitch, but slowly fade away.

“It was certainly very unexpected to see something that didn’t chirp,” says physicist Jolyon Bloomfield of MIT, who was not involved with the research. “This is really quite interesting work. It shows that the chirp actually goes away — something else is happening here.”

If such black hole mergers occur in nature, next-generation gravitational wave observatories like the Evolved Laser Interferometer Space Antenna might provide proof of their existence. Plans call for eLISA to measure gravitational waves from space beginning in 2034. “These are definitely detectable with eLISA,” Warburton said.

The Advanced Laser Interferometer Gravitational-Wave Observatory, which made the first detection of gravitational waves in 2015 (SN: 3/5/16, p. 6), might be able to observe such mergers if the conditions were just right. Although LIGO can’t observe the mergers of black holes as massive as Gargantua, smaller spinning black holes would produce a similar effect.
Finding black holes like Gargantua would have an impact beyond Hollywood. Spinning black holes are “really interesting from a fundamental physics point of view,” says Samuel Gralla of the University of Arizona in Tucson, a coauthor on the new paper.

Black holes can spin up faster and faster as they suck in matter, but scientists think there’s a limit to how fast they can go. At the center of a black hole is a singularity, or region of infinite density, which is hidden by an event horizon — the surface beyond which nothing can escape the black hole’s greedy pull. But if the black hole twirls too fast, the singularity becomes exposed. Such a “naked singularity,” as it is known, is thought to be impossible to reach, because the known laws of physics would break down.

According to the scientists’ calculations, black hole mergers sing when the larger black hole is rotating just below the limit, at 99.99 percent of its maximum speed. This makes singing black holes an enticing prospect for understanding physics at its extremes.

Over the years, readers have on occasion written to me to point out what they see as an increasing politicization of Science News. These are not accolades — more than one of those readers has contemplated ending their subscription. Some of those critics deny climate change, some oppose GMOs, others view any policy discussion in our coverage as worrisome. So, are we actually getting involved in politics?
My short answer is no. But there are many areas in which science has important things to say to citizens and policy makers. And reporting on the body of evidence that relates to societal issues falls fully within our mission, even for scientific questions with political ramifications. It’s well worth the ink to inform people about pressing problems or provide factual information in what have become hotly contested and polarizing debates.
Science can help establish what’s known, what’s not known and how scientists might find answers. That’s what Science News reports on, with the aim of giving readers not a political argument but a clear idea of where the evidence currently stands and what questions remain. Facts based on sound science can perhaps even provide a common ground for people of differing opinions to speak to each other rationally.

In the case of what researchers can say with respect to the efficacy of gun laws, it turns out that there are more questions than answers. The numbers on U.S. gun violence are clear: In 2013, the United States had many more gun-related deaths than other nations with similar standards of living. But as Meghan Rosen investigated the state of the knowledge, it became evident that now, in the United States, it’s hard to even do the science. Researchers told her that they just don’t have the data needed to answer questions about the impacts of different gun control laws.

“I thought the evidence behind well-known gun control policies would be more clear-cut,” Rosen says. But studies of background checks, waiting periods and a 1994 assault weapons ban don’t necessarily show a corresponding reduction in gun violence. Maybe such laws don’t do what lawmakers intended, but there are also confounding factors that may dilute any conclusions, Rosen reports. The 1994 ban on assault weapons, for example, stopped only sales of new weapons and didn’t apply to those already in circulation. Most disturbing to Rosen was the blocking of scientific research by Congress, which has maneuvered to stop the Centers for Disease Control and Prevention and the National Institutes of Health from doing or funding work that might advocate or promote gun control laws. That has effectively reduced research into the best ways to prevent gun violence.

The science that has been done on whether U.S. gun control laws reduce gun violence has been mixed. There aren’t a lot of straightforward answers to guide policy. But in this case, science has not had a fair chance to build the foundation for an evidence-based conversation. Without facts, it really is all political. Our aim is to find and report on those facts (or the lack of them), so that they can become part of the conversation.

A gut microbe collected from chinchilla droppings might be the first complex life form to lack even a shred of a supposedly universal organelle.

Monocercomonoides, a one-celled gut microbe collected from a pet chinchilla in Prague decades ago, apparently has no mitochondria, the organelles known as the cell’s power plants. Cataloging DNA in the microbe turns up none of the known genes for mitochondrial proteins. But stealing genetic material from bacteria — which survive without mitochondria — allowed the microbe to do without them, too, researchers report May 12 in Current Biology.
Mitochondria are tiny capsules that speckle the insides of all complex cells from pond scum to people, or so textbooks have said for decades. Some complex (or eukaryotic) cells look as if they have no mitochondria; so far, though, further searches have eventually detected mitochondrial remnants.

But Monocercomonoides appears to have completely done away with mitochondria and the genes to make them, says study coauthor Anna Karnkowska, an evolutionary biologist now at the University of British Columbia in Vancouver.

This discovery marks “the most extreme mitochondrial reduction observed,” says Vladimír Hampl of Charles University in Prague, also a coauthor of the study.

The new work also supports the idea that there really is no single core function that defines mitochondria. Although commonly described as cell powerhouses, mitochondria don’t have much to do with supplying energy for cells that live in low-oxygen or no-oxygen environments, Karnkowska says. For these anaerobic cells, mitochondria can serve as more of a building studio. One supposedly essential mitochondrial function, scientists have proposed, is assembling clusters of iron and sulfur that activate a class of widely useful cell compounds.

Bacteria and other simple (prokaryotic) cells have their own assembly systems, and they don’t need to wall off the construction of iron-sulfur clusters. The newly studied Monocercomonoides carry the genes for an assembly system that looks as if it was taken from bacteria, the researchers conclude.
Researchers discovered the lack of mitochondrial genes and the bacterial substitute while working out the DNA components that encode instructions for all the proteins in the whole organism. There were notably no signs of chaperone proteins for conveying other proteins through membranes, something mitochondria do. Nor did other signature mitochondrial proteins show up.

“Pretty amazing story,” says Roland Lill of Philipps University of Marburg in Germany, who studies the way cells use iron. The new paper doesn’t change the basic idea that complex cells need very special conditions, usually created only inside mitochondria, to build their iron-sulfur clusters. “But the beauty of biology,” he says, “is that there are always amazing exceptions to basic biological rules.”

Laser blasts might help scientists tweak Earth’s thermostat by shattering the ice crystals found in cirrus clouds.

Zapping tiny ice particles in the lab forms new, smaller bits of ice, researchers report May 20 in Science Advances. Since clouds with more numerous, smaller ice particles reflect more light, the technique could combat global warming by causing the clouds to reflect more sunlight back into space, the scientists say.

Scientists from the University of Geneva and from Karlsruhe Institute of Technology in Germany injected water drops into a chilled chamber that mimics the frigid conditions high in the atmosphere, where wispy cirrus clouds live. The water froze into spherical ice particles, which the scientists walloped with short, intense bursts of laser light.
When the laser hits an ice particle, ultrahot plasma forms at its center, producing a shock wave that breaks the particle apart and vaporizes much of the ice. The excess water vapor left in the aftermath then condenses and freezes into new, smaller ice particles.
Applying this technique to clouds is “a long, long, long way in the future,” says physicist Mary Matthews of the University of Geneva, a coauthor of the study. Current laser technology is not up to the task of cloud zapping — yet. “What we are hoping for is that the advances in laser technology, which are moving faster and faster all the time, will enable high-powered, mobile lasers,” Matthews says.

But tinkering with cirrus clouds could backfire if scientists aren’t careful, says atmospheric scientist Trude Storelvmo of Yale University. The clouds also trap heat, through the greenhouse effect, so breaking up their ice particles could actually warm the Earth. The method“could potentially work, but only if you target certain types of cirrus clouds,” she says, such as those that are very thick.

There could also be warming if fossil fuels are burned to power the laser, says David Mitchell of the Desert Research Institute in Reno, Nev. “I think it’s really interesting research, but I’m just not seeing how it’s going to make the world a cooler place.”

U.S. 191 is one of the driving options for people headed to Grand Teton or Yellowstone National Parks. But the road also cuts through prime territory for mule deer and pronghorns. And cars and large wildlife don’t usually mix well. When they do tangle, the cars end up heavily damaged, and the animals end up dead.

In an effort to reduce this conflict, the Wyoming Department of Transportation spent nearly $10 million to install two overpasses and six underpasses, along with deer-proof fencing, on sections of the highway near Daniel Junction in 2012. The sites for the passes were chosen based, in part, on the migration patterns of mule deer and pronghorns through the area.

Shortly after the installation, the animals were seen using the crossings, and vehicle collisions appeared to decline. The project was labeled a success. Now, an analysis of the project finds just how successful it has been: Car collisions with pronghorn have disappeared entirely and those with mule deer have dropped by 79 percent, Hall Sawyer of Western Ecosystems Technology Inc., and colleagues report May 16 in the Wildlife Society Bulletin.

Two digital cameras were installed at each overpass and one at each underpass to monitor wildlife using the crossings during the spring and fall migration periods in 2012 through 2015. Thousands of animals started using the pathways, and each year, more and more animals crossed the highway using these safe paths. Over the years, 40,251 mule deer and 19,290 pronghorn made their way through the passages.

Of the mule deer passing through, 79 percent used the underpasses. But among pronghorns, 92 percent took the overpasses. This confirms something that researchers had thought would be true but never really had any data to back up. They figured that ungulates such as pronghorns that live in open areas and are heavily reliant on vision to detect predators should prefer overpasses, because the structures would allow the animals to have better vision and movement. The new finding supports this, at least for pronghorns, and shows that building overpasses, which are more expensive than paths beneath highways, really is necessary for some animals.

This area of U.S. 191 was one of the worst for wildlife vehicle collisions before the crossings were built, averaging 85 per year from 2005 to 2012. By the third year after the installation, though, collisions had dropped to just 16 per year.

When the crossings were put in place, the Department of Transportation claimed that, by preventing vehicle collisions, the project would essentially pay for itself in 20 years. But this project has been so successful, the team calculates, that a crossing could pay for itself in just 4 years. And then, of course, there’s the benefit for the wildlife itself, which can now more easily and safely move through the landscape.
The team does note that Wyoming did have to make a few adjustments to the project to accommodate human behavior. The overpasses are edged with high berms to prevent animals from seeing the highway, but those berms proved tempting to ATV users and motorcyclists. Because this activity is damaging to vegetation and could reduce effectiveness of the crossings, the Bureau of Land Management had to post signs warning people away.

And when the crossings first went up, some canny hunters figured that the overpasses were good spots to find hundreds of pronghorn; hunting is now banned within 800 meters of a wildlife overpass.

A newly discovered species of tomato belongs in a haunted house, not on a sandwich.

Fruit from the bush tomato plant Solanum ossicruentum bears little resemblance to its cultivated cousins. The Australian tomato, about a couple centimeters wide, grows enclosed in a shell of spikes. These burrs probably help the fruit latch on to the fur of passing mammals, which then spread the tomato’s seeds elsewhere, researchers at Bucknell University in Lewisburg, Pa., report May 3 in PhytoKeys.

Slice open the fearsome fruit and within five minutes, its sticky white-green flesh appears to bleed, flushing bright red to dark maroon in response to air exposure. One brave researcher tasted an unripe fruit and deemed it salty. The bush tomato becomes no more appetizing with time: Mature fruits harden into dry, bony nuggets.

The tomato’s gruesome qualities inspired its name, courtesy of a group of Pennsylvanian seventh-grade science students: “Ossicruentum” combines the Latin words for “bone” and “bloody.”

Social media supporters of the Islamic State, or ISIS, form online groups that may provide clues crucial to predicting when terrorist attacks will take place, a new analysis finds.

These virtual communities drive ISIS activity on a Facebook-like site called VKontakte, say physicist Neil Johnson of the University of Miami in Coral Gables, Fla., and colleagues. VKontakte, a social networking service based in Russia with more than 350 million users, allows messaging in many languages and is used worldwide.
In the June 17 Science, Johnson’s team describes a mathematical model that predicts online groups of ISIS supporters will proliferate days before real-world Islamic State attacks. That’s just what happened in September 2014, researchers say. Pro-ISIS groups on VKontakte mushroomed the day before Islamic State forces overran Kobane, a small Syrian town.

The researchers refer to groups of followers of an online page that form spontaneously as aggregates. “Our work suggests that, to manage and monitor online ISIS activity, we need to focus on aggregates rather than individuals,” Johnson says.

Pro-ISIS aggregates on VKontakte exchanged information on issues such as recruiting fighters to Syria and how to survive drone attacks.

The new model suggests that authorities need to shut down online pro-ISIS groups in their early stages. Small-scale aggregates favoring the same cause gradually expand when left alone and eventually merge into a much larger online community that’s more difficult to break up, Johnson’s model forecasts.

“This is the first serious, large-scale, data-driven study that shows how online support develops for terrorist groups such as ISIS,” says computer scientist V.S. Subrahmanian of the University of Maryland in College Park, who builds computational models of terror networks. But it remains to be seen whether the new model can predict when and possibly where future Islamic State attacks will occur, Subrahmanian cautions.
Johnson’s team identified 196 pro-ISIS aggregates, consisting of 108,086 individual followers, which operated between January 1 and August 31, 2015. Intelligence agencies, hackers and website moderators work to shut down these online groups, but to a lesser extent on VKontakte than on Facebook.

Pro-ISIS aggregates rapidly adapted to these survival threats in several ways, the researchers say. Fifteen percent of aggregates changed their online names; 7 percent flipped back and forth between opening their content to any VKontakte user or to current aggregate followers only; and 4 percent engaged in a digital form of reincarnation. Pro-ISIS aggregates under unusually intense attack by hackers and others opted for reincarnation, Johnson says.

Reincarnating aggregates disappeared and then returned, often within weeks, with new names and at least 60 percent of the same followers as before. Aggregates that vanished appear to have reassembled without any direction or urging from one or a few members, Johnson says. New names of reincarnated groups often resembled original names enough to alert former members but not enough to trigger VKontakte’s automated system for identifying names of probable pro-militant groups, he points out.

As with predictions of terror attacks based on the expansion of pro-ISIS aggregates, the new model shows promise in predicting when mass public protests will occur based on sudden jumps in numbers of pro-protest aggregates, the scientists say. There is a difference: Reincarnation did not appear within the last three years among Facebook aggregates consisting of civil protesters in Brazil and several other Latin American countries, the researchers found. Those online groups experienced fewer pressures to shut down than pro-ISIS aggregates on VKontakte did.

Johnson’s analysis moves the study of online militant groups forward, says terrorism analyst J.M. Berger of George Washington University in Washington, D.C. But it’s likely that considerably fewer members of pro-ISIS aggregates than the total studied in the new analysis were actually hard-core Islamic State supporters, Berger contends. Concerted efforts to shut down online terrorist networks have depressed numbers of committed ISIS supporters using social media, in his view. Berger and a colleague have found that English-language Twitter use has declined sharply among ISIS supporters over the last two years, due to suspensions of their accounts by the social media site.

Johnson suspects most pro-ISIS aggregate members were staunch supporters, since aggregates aggressively weed out those deemed unserious or hostile.

Terrorists use chains of social and messaging sites online to achieve their ends, Subrahmanian says. How that works, and whether the same aggregate operates under different guises from one site to the next, has yet to be studied.

Scientists have found a new way to study how cancer cells divide and thrive in difficult-to-reach crannies of the body.

Transparent artificial membranes — just nanometers thick — can be rolled into tubes to mimic capillaries that host spreading cancer cells, researchers report in the June ACS Nano. Cells squished inside such tubes didn’t organize their internal components the way they normally do before splitting. As a result, the cells divided unevenly, potentially introducing new mutations.
Inside the body, cancer cells fight for space. Sometimes they’ll spread, or metastasize, to other organs via tight blood vessels. Although cancer cells are more likely to kill once they spread, scientists still don’t understand how the abnormal cells divide inside such tiny tubes. These cells are difficult to study in the body because they’re tucked away in hard-to-reach places. They’re challenging to study in the lab, too, because they behave differently in a petri dish than in their natural environment.

By replicating that environment more closely, this experiment gives “an appreciation for what it’s like to be a cell in a body,” says Buzz Baum, a biologist at University College London who was not involved in the work.

Other researchers have looked at cells constrained in other ways. But the nanotubes are round, just like blood vessels. They’re transparent, making it easier to visualize what’s happening inside. And it’s possible to study many cells at once by growing nearly a thousand tubes, all exactly the same size, on a chip slightly larger than a postage stamp.

When watching single human cancer cells inside the tubes through high-powered microscopes, the team noticed that the squished cells didn’t divide symmetrically. Instead of sending half the chromosomes to each new cell, some of those cells got extra genetic instructions, while others were shortchanged.

The squished cells also took longer to divide. And the protein structures that help guide the chromosomes and organelles into place before division didn’t develop correctly, says study coauthor Wang Xi, a materials scientist who did the work at the Leibniz Institute for Solid State and Materials Research Dresden in Germany.
Cancer cells succeed by mutating enough that they can evade capture, without becoming too mutated to keep replicating.

“A cell that makes too many mistakes will just die,” says Baum.

When cells are trapped inside blood vessels, “they become misshapen but they’re still able to divide,” says Xi, now at the National University of Singapore.

Xi and his colleagues think that a bulging of the cell membrane in response to pressure, called blebbing, might help the trapped cells divide in a slightly less distorted way. When the researchers prevented the cells from blebbing, the division was even more uneven. But because the team can’t yet explain why this would be the case, it’s too soon to say whether blebbing itself is responsible for the improved division.

Baum says he has shown similar deformities in cancer cells dividing under other types of constraints. But, he adds, it’s important to have systems that more closely replicate the body’s internal environment. Otherwise, it can be a big jump between doing tests in a petri dish and in a live animal.

Study coauthor Christine Schmidt, a biochemist at the University of Cambridge, says understanding how cancer cells manage to divide in tight quarters could eventually inspire ways to kill spreading cancer cells without hurting healthy cells.