A baby boy born on April 6 is the first person to be born from a technique used to cure mitochondrial diseases, New Scientist reports.

The child’s mother carries Leigh syndrome, a fatal disease caused by faulty mitochondria. Mitochondria generate most of a cell’s energy and perform other functions that keep cells healthy. Each mitochondria has a circle of DNA containing 37 genes needed for mitochondrial function. A mutation in one of those genes causes Leigh syndrome. The woman herself is healthy, but previously had two children who both died of Leigh syndrome.

John Zhang, a fertility doctor at New Hope Fertility Center in New York City, and colleagues transferred a structure called the spindle with chromosomes attached to it from one of the woman’s eggs into a healthy, empty donor egg. The resulting egg was then fertilized with sperm from the woman’s husband. The procedure was done in Mexico.

The technique, called spindle nuclear transfer, is one of two ways of creating “three-parent babies” to prevent mitochondrial diseases from being passed on. Such three-parent babies inherit most of their DNA from the mother and father, but a small amount from the donor. Other three-parent children who carried mitochondria from their mothers and from a donor were born in the 1990s, but the baby boy is the first to be born using a nuclear transfer technique. Zhang and colleagues will report the successful birth October 19 in Salt Lake City at the American So

A GPS app can plan the best route between two subway stops if it has been specifically programmed for the task. But a new artificial intelligence system can figure out how to do so on the fly by learning general rules from specific examples, researchers report October 12 in Nature.

Artificial neural networks, computer programs that mimic the human brain, are great at learning patterns and sequences, but so far they’ve been limited in their ability to solve complex reasoning problems that require storing and manipulating lots of data. The new hybrid computer links a neural network to an external memory source that works somewhat like RAM in a regular computer.

Scientists trained the computer by giving it solved examples of reasoning problems, like finding the shortest distance between two points on a randomly generated map. Then, the computer could generalize that knowledge to solve new problems, like planning the shortest route between stops on the London Underground. Rather than being programmed, the neural network, like the human brain, responds to training: It can continually integrate new information and change its response accordingly.

The development comes from Google DeepMind, the same team behind the Alpha Go computer program that beat a world champion at the logic-based board game.

Clever chemistry could take the salt out of water softening.

Aluminum ions can strip minerals from water without the need for sodium, researchers report online October 4 in Environmental Science & Technology. The new technique could sidestep health and environmental concerns raised about the salt released by existing sodium-based water softening systems, says study coauthor Arup SenGupta.

“This is a global need that hasn’t been met,” says SenGupta, an environmental engineer at Lehigh University in Bethlehem, Pa. “We’re just changing the chemistry by adding aluminum ions, which is not something outlandish, but with that we can reduce the environmental impact.”
Hard water contains dissolved minerals such as calcium and magnesium that make it harder for soap to lather and that can leave scaly deposits inside faucets and showerheads. Many water softening systems combat these problems by passing water through a special tank containing beads covered in sodium ions, charged particles that can swap places with the calcium and magnesium, resulting in softer water.

This technique adds extra sodium to the outgoing water, though, which can raise blood pressure when used as drinking water (SN Online: 3/12/14). The system also has to be recharged periodically using a sodium-rich brine. That extra salt can end up in local groundwater and streams, prompting bans on salt-based water softeners in many areas, including many counties in California.
While some sodium-free substitutes exist, many are expensive while others are “snake oil” and don’t actually work, SenGupta says. He and colleagues decided to try aluminum, a counterintuitive choice based on its chemistry. An aluminum ion has a net positive charge of three, meaning that it has three fewer negatively charged electrons than a neutral aluminum atom. That charge difference makes it less likely for aluminum to swap places with a calcium or magnesium ion, which each have a positive charge of two.
But when an ion exchange does happen, the aluminum often quickly precipitates back onto the water softener’s beads rather than dissolving into the water and being swept away. The process allows the same aluminum ion to swap in for multiple calcium and magnesium ions.
Setting up a prototype water softening system in the laboratory, the researchers successfully reduced the amount of calcium and magnesium in a groundwater-like mixture using aluminum ions. Recharging the system also resulted in fewer wasted ions than sodium-based systems, the researchers found, lowering the potential environmental impact. The process uses a similar setup to sodium-based systems, SenGupta says, meaning existing systems could be easily retrofitted to use aluminum ions.

While an exciting idea, the new design might not work as well in real life as it does in the lab, says Steven Duranceau, an environmental engineer at the University of Central Florida in Orlando. Bacteria and other substances in groundwater can reduce effectiveness, and strict guidelines surrounding drinking water could prove an unsurmountable hurdle, he says. “I see these great things all the time, but a lot of them just don’t make it financially.”

SenGupta remains optimistic, though. “This is not a magic bullet; there are shortcomings, but none of these problems are impossible to overcome.”

This forlorn-looking face of a 4-day-old zebrafish embryo represents “a whole new avenue of research” for geneticist Oscar Ruiz, who studies how faces and facial abnormalities develop at the cellular level.

The research is possible thanks to a new method, developed by Ruiz and colleagues at the University of Texas MD Anderson Cancer Center in Houston, for mounting embryos in a gel that allows for clear, head-on pictures. A technique called confocal microscopy captures images like the one above, the first-place winner of this year’s Nikon Small World photography contest.
The embryo was euthanized before having its picture taken. But Ruiz is experimenting with taking time-lapse images of live, anesthetized zebrafish embryos. The camera snaps an image every five minutes for up to 48 hours, meaning that “we’re able to watch the development happening,” Ruiz says.

So far, the team has looked at embryos ranging from 1 to 6 days old. The researchers are compiling the images into an atlas documenting the developmental stages of the zebrafish face. They plan to use CRISPR/Cas9, a powerful gene-editing tool, to alter genes involved in facial abnormalities in the fish and then watch what changes, if any, occur. The research could one day be used to help scientists understand how a cleft lip or cleft palate develops in humans and possibly help treat it, Ruiz says.

In the image above, shown at 10x magnification, basal cells (green) in the bottom layer of skin give rise to more developed surface skin cells (red). Cell nuclei appear in blue.

“Everyone’s first impression is that those two holes in the center are its developing eyes,” Ruiz says. But they’re not. Those deceptive hollows are nascent olfactory tissue, used to smell. The eyes are actually the big bulges on either side of the face.
Although this was the first time Ruiz entered the microscopy photography contest, he is an amateur photographer. Landscape or travel photos — not fish photos — are his subject matter of choice.

Here are more finalists and honorable mentions from the competition:

El Niño’s meteorological sister, La Niña, has officially taken over.

This year’s relatively weak La Niña is marked by unusually cool sea surface temperatures in the central and eastern equatorial Pacific Ocean. That cold water causes shifts in weather patterns that can cause torrential downpours in western Pacific countries, droughts in parts of the Americas and more intense Atlantic hurricane seasons.

The event has about a 55 percent chance of sticking around through the upcoming Northern Hemisphere winter and is expected to be short-lived, the National Oceanic and Atmospheric Administration’s Climate Prediction Center reported November 10.

In a hotel ballroom in Seoul, South Korea, early in 2016, a centuries-old strategy game offered a glimpse into the fantastic future of computing.

The computer program AlphaGo bested a world champion player at the Chinese board game Go, four games to one (SN Online: 3/15/16). The victory shocked Go players and computer gurus alike. “It happened much faster than people expected,” says Stuart Russell, a computer scientist at the University of California, Berkeley. “A year before the match, people were saying that it would take another 10 years for us to reach this point.”
The match was a powerful demonstration of the potential of computers that can learn from experience. Elements of artificial intelligence are already a reality, from medical diagnostics to self-driving cars (SN Online: 6/23/16), and computer programs can even find the fastest routes through the London Underground. “We don’t know what the limits are,” Russell says. “I’d say there’s at least a decade of work just finding out the things we can do with this technology.”

AlphaGo’s design mimics the way human brains tackle problems and allows the program to fine-tune itself based on new experiences. The system was trained using 30 million positions from 160,000 games of Go played by human experts. AlphaGo’s creators at Google DeepMind honed the software even further by having it play games against slightly altered versions of itself, a sort of digital “survival of the fittest.”

These learning experiences allowed AlphaGo to more efficiently sweat over its next move. Programs aimed at simpler games play out every single hypothetical game that could result from each available choice in a branching pattern — a brute-force approach to computing. But this technique becomes impractical for more complex games such as chess, so many chess-playing programs sample only a smaller subset of possible outcomes. That was true of Deep Blue, the computer that beat chess master Garry Kasparov in 1997.

But Go offers players many more choices than chess does. A full-sized Go board includes 361 playing spaces (compared with chess’ 64), often has various “battles” taking place across the board simultaneously and can last for more moves.

AlphaGo overcomes Go’s sheer complexity by drawing on its own developing knowledge to choose which moves to evaluate. This intelligent selection led to the program’s surprising triumph, says computer scientist Jonathan Schaeffer of the University of Alberta in Canada. “A lot of people have put enormous effort into making small, incremental progress,” says Schaeffer, who led the development of the first computer program to achieve perfect play of checkers. “Then the AlphaGo team came along and, incremental progress be damned, made this giant leap forward.”

Real-world problems have complexities far exceeding those of chess or Go, but the winning strategies demonstrated in 2016 could be game changers.

The last time Earth’s thermostat was cranked as high as it is today, sea levels were high enough to completely drown New Orleans (had it existed at the time), new research suggests.

Ocean surface temperatures around 125,000 years ago were comparable to those today, researchers report in the Jan. 20 Science. Previous estimates suggested that this period, the height of the last warm phase in the ongoing ice age, was as much as 2 degrees Celsius warmer.
Climate scientists often use the last interglacial period as a reference point for predicting how rising temperatures will affect sea levels. The new results, the researchers write, will help scientists better predict how Earth’s oceans and climate will respond to modern warming. Warming 125,000 years ago raised sea levels 6 to 9 meters above present-day levels.

The global scale of that warming has been difficult to estimate. Chemical clues inside dozens of seafloor sediment samples collected from around the world provide only regional snapshots of the ancient climate. Combining 104 of these dispersed data points, climate scientist Jeremy Hoffman of Oregon State University in Corvallis and colleagues pieced together a global climate picture.

Average global sea surface temperatures around 125,000 years ago were indistinguishable from the 1995 to 2014 average, the researchers estimate.

The playground ditty “first the worst, second the best” isn’t always true when it comes to dengue fever. Some patients who contract the virus a second time can experience more severe symptoms. A rogue type of antibody may be to blame, researchers report in the Jan. 27 Science. Instead of protecting their host, the antibodies are commandeered by the dengue virus to help it spread, increasing the severity of the disease.

Four closely related viruses cause dengue, a mosquito-transmitted disease marked by fever, muscle pain and other flulike symptoms. When a previously infected person contracts a second type of dengue, leftover antibodies can react with the new virus.
Fewer than 15 percent of people with a second infection develop severe dengue disease. Those who do may produce a different type of antibody, says Taia Wang, an infectious diseases researcher with the Stanford University School of Medicine.

Wang and colleagues found that dengue patients with a dangerously low blood platelet count — a sign of severe dengue disease — had an abundance of these variant antibodies.

Tests in mice supported the connection. “We found that when we transferred the antibodies from patients with severe disease into mice, they triggered platelet loss,” Wang says.

Wang says it’s not known why some people have this alternate antibody. She and her team want to determine that, along with how these antibodies are regulated by the immune system. With further research, they may be able to screen people to identify those more susceptible to severe dengue disease, Wang says.

Anna Durbin, a dengue vaccine researcher at the Johns Hopkins Bloomberg School of Public Health, doesn’t see a strong connection between this type of antibody and the severity of dengue disease. But she says that the research was interesting in how it connected dengue to low platelet count, a condition known as thrombocytopenia.

“There’s a lot of different theories out there about the role of dengue antibodies and thrombocytopenia, and whether or not the virus itself can enter platelets,” Durbin says. “I think this paper may provide more insight into what is the pathogenic mechanism of thrombocytopenia and dengue, and raises some good avenues for further research.”

Fearful, flighty chickens raised for eating can hurt themselves while trying to avoid human handlers. But there may be a simple way to hatch calmer chicks: Shine light on the eggs for at least 12 hours a day.

Researchers at the University of California, Davis bathed eggs daily in light for different time periods during their three-week incubation. When the chickens reached 3 to 6 weeks old, the scientists tested the birds’ fear responses. In one test, 120 chickens were randomly selected from the 1,006-bird sample and placed one by one in a box with a human “predator” sitting visibly nearby. The chickens incubated in light the longest — 12 hours — made an average of 179 distress calls in three minutes, compared with 211 from birds incubated in complete darkness, animal scientists Gregory Archer and Joy Mench report in January in Applied Animal Behaviour Science.

Chickens exposed to lots of light as eggs “would sit in the closest part of the box to me and just chill out,” Archer says. The others spent their time trying to get away. How light has its effect is unclear. On commercial chicken farms, eggs typically sit in warm, dark incubation rooms. The researchers are now testing light’s effects in large, commercial incubators. Using light exposure to raise less-fearful chickens could reduce broken bones during handling at processing plants, Archer says. It might also decrease harmful anxious behaviors, such as feather pecking of nearby chickens.

Babies are born germy, and that’s a good thing. Our microbiomes — the microbes that live on and in us — are gaining cred as tiny but powerful keepers of our health.

As microbes gain scientific stature, some scientists are trying to answer questions about how and when those germs first show up on babies. Birth itself may be an important microbe-delivery event, some researchers suspect. A trip through the birth canal can coat a baby with bacteria from his mother. A C-section, some evidence suggests, might introduce different bacteria, at least right after birth.

That difference forms the basis of the practice of vaginal seeding, which involves wiping vaginal fluids onto a baby born by C-section to introduce microbes the baby would have encountered in a vaginal birth.

Even while some parents are asking for the procedure, there’s dissent in the ranks of research about its benefits. Scientists don’t agree yet on how — or even whether — type of birth affects the microbiome. “It’s murky,” says obstetrician and maternal-fetal medicine specialist Kjersti Aagaard of the Baylor College of Medicine in Houston. Existing studies don’t clearly distinguish the effects of the C-section itself from those of certain diseases or conditions that can make a C-section more likely, such as maternal diabetes or obesity, she says. Other issues, like whether a baby received antibiotics or is breastfed, also muddy the waters. “You are left saying, ‘Wait a minute. Is it the surgery or not the surgery? What’s going on here?’” Aagaard says.

In a search for clarity, Aagaard and her colleagues surveyed the microbiomes of 81 pregnant women. Later on, the researchers added a second group of 82 women, whose microbiomes were assessed at the birth of their children.

Just after birth, babies who had been delivered by C-section had different mouth, nose and skin microbiomes than babies born vaginally. One possible explanation is that these babies are handled differently just after birth, Aagaard says. The microbiomes of the babies’ meconium, or stool, appeared to be similar, regardless of how the babies were born.

But between four and six weeks later, these C-section/vaginal birth differences on the mouth, nose and skin were largely gone, Aagaard says. The microbes living in and on the babies born by C-section and those born vaginally were nearly indistinguishable, the researchers reported online January 23 in Nature Medicine.
Depending on where they lived, the populations of microbes had already taken on distinct identities by about a month after birth, the researchers found. Communities of nose-dwelling microbes were easy to distinguish from those living in the gut, for instance. These regional differences are signs of surprising microbial maturity, Aagaard says. “Postnatal microbiomes start looking like adults a little sooner than we may have appreciated,” she says.

The results raise an interesting question: If the type of birth isn’t one of the main shapers of microbiomes, then how and when do microbes get into babies? It’s possible that microbes from mothers slip into fetuses during pregnancy — a plausible idea, given some earlier results. Genetically tagged bacteria fed to pregnant mice showed up in their fetuses’ guts a day before the predicted due date, a result that suggests the bacteria traveled from mother to fetus. And Aagaard and colleagues have found evidence of microbes in the placenta of human mothers. They are now studying whether microbes, or perhaps pieces of them, move through the placenta from mother to baby. If that turns out to be the case, then babies meet their microbes, for better or worse, well before their birthday.